Effect of Robusta coffee extract gel on fibroblast and collagen during proliferative phase of IIB degree-burn on Long Evans rats

IIB Degree-burn takes longer to heal because only a small epithelium component remains. It requires topical agent that can accelerate the wound healing process. One of signs is increased collagen formation as an extracellular matrix produced by fibroblast in proliferative phase. This study aimed prove effect Robusta coffee extract gel on increasing number fibroblasts and density degree-burn treatment Long Evans rats. used 24 rats which were divided into three groups, namely positive control (silver sulfadiazine), negative (gel base), group (2.5% gel). The results showed higher (p<0.05) denser compared day 8 14. These indicated increases scavenge free radicals stimulate release cytokines play role proliferation. affects expanding be alternative second-degree burns treatment.